Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice

Inflammatory T helper 17 cells promote depression-like behavior in mice.

BACKGROUND Recognition of substantial immune-neural interactions is revising dogmas about their insular actions and revealing that immune-neural interactions can substantially impact central nervous system functions. The inflammatory cytokine interleukin-6 promotes susceptibility to depression and drives production of inflammatory T helper 17 (Th17) T cells, raising the hypothesis that in mouse...

Fibroblast and T cells conditioned media induce maturation dendritic cell and promote T helper immune response

Dendritic cells (DCs) induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), PHA activated T cells (T cell conditioned medium), and mixture of fibroblast & PHA activated T cells (FCM-TCCM) conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. ...

T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.

BACKGROUND & AIMS T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS We analyzed intestinal Th17 cells in healthy and inflamed intestinal tissues of mice. We analyzed expression of lympho...

the roles of t helper 1, t helper 17 and regulatory t cells in the pathogenesis of sarcoidosis

sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...

T-helper-17, Regulatory T-helper Cells Related Serum Markers and IL-13 in the Outcome of Polytraumatic Patients with Bacteremia